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Western blot analysis of extracts of various cell lines, using MAPK8IP1 antibody (A9011) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 15s.
MAPK8IP1 Rabbit pAb
Catalog No：AB-A9011
Manufacturer：ABclonal
Synonyms：MAPK8IP1;IB1;JIP-1;JIP1;PRKM8IP
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | MAPK8IP1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MAPK8IP1 (NP_005447.1). |
| Gene ID: | 9479 |
| Swiss prot: | Q9UQF2 |
| Molecular weight: | 77kDa |
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