CD274 Rabbit pAb
Catalog No：AB-A20481
Manufacturer：ABclonal
Synonyms：PD-; B7h1; Pdl1; Pdcd1l; Pdcd1l1; Pdcd1lg1; A530045L16Rik
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€110,00 – €325,00
| Product Name: | CD274 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. |
| Immunogen: | Recombinant protein of Mouse CD274. |
| Gene ID: | 60533 |
| Swiss prot: | Q9EP73 |
| Molecular weight: | 32kDa |
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